Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice.

The deficiency of n-3 PUFAs in the brain and depressive symptoms are closely related. Krill oil contains abundant amounts of n-3 PUFAs incorporated in phosphatidylcholine.However, the effect of krill oil treatment on depression-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, we used a chronic unpredictable mild stress (CUMS) model to evaluate the effect of krill oil on depression-like behaviors and explored its molecular mechanism through lipid metabolomics and mRNA profiles in the whole brain. Overall design: Brains of four differently treated C57/BL6J mice, control group, krill oil group, CUMS group and CUMS+krill oil group

大脑中n-3多不饱和脂肪酸（n-3 PUFAs）缺乏与抑郁症状密切相关。磷虾油富含结合于磷酯酰胆碱（phosphatidylcholine）中的n-3多不饱和脂肪酸。然而，磷虾油干预对慢性应激诱导的抑郁样行为的作用及其在大脑中的分子机制，目前仍不甚明确。本研究采用慢性不可预见性温和应激（chronic unpredictable mild stress, CUMS）模型评估磷虾油对抑郁样行为的影响，并通过全脑脂质代谢组学与mRNA表达谱分析，探究其潜在的分子机制。实验设计：选取经四种不同干预处理的C57/BL6J小鼠脑组织，分为对照组、磷虾油组、慢性不可预见性温和应激组以及慢性不可预见性温和应激+磷虾油联合干预组。