Human skeletal muscle biopsies from a 3h IL-6 infusion. Homo sapiens

Skeletal muscle has been identified as a secretory organ. We hypothesized that IL-6, a cytokine secreted from skeletal muscle during exercise, could induce production of other secreted factors in skeletal muscle. Keywords: Human skeletal muscle time course response to IL-6 infusion Overall design: IL-6 was infused for 3 h into healthy young males (n=7) and muscle biopsies obtained at time points 0, 3 and 6 h in these individuals. Affymetrix microarray analysis of gene expression profiling in muscle were carried out on 3 randomly chosen subjects.

骨骼肌已被证实为一种分泌器官。我们提出假说：运动过程中由骨骼肌分泌的细胞因子白细胞介素-6（IL-6），可诱导骨骼肌产生其他分泌型因子。
关键词：人骨骼肌对IL-6输注的时序应答反应
实验设计：向7名健康年轻男性（n=7）输注IL-6时长3小时，并在上述受试者的0、3、6小时时间点采集肌肉活检样本。针对3名随机选取的受试者，对其肌肉组织开展了基因表达谱的Affymetrix微阵列分析。