Genes whose expression is regulated by EBNA3B and EBNA3A in LCLs.

Genes are grouped into those down-regulated in EBNA3A and 3B knockout LCLs (top part), up-regulated in both (middle), and regulated in different directions in the two mutants (Bottom). For each gene, data for all of the Affymetrix U133plus2 probesets mapped to that gene are included. ANOVA p-values and fold changes are shown for 3BKO-LCL vs wtBAC LCL and for 3AmutB LCL vs WT LCL. Affymetrix IDs are bold where p<0.001 and fold change >1.5. Data are bold where p<0.001 or fold change >2.
Genes in italics passed significance thresholds for all EBAN3A mutants vs WT, but not quite for 3AmutB vs WT. The changes seen in the gene's expression in BL31 cells are indicated in the final column.

基因被分为三类：在EBNA3A与EBNA3B敲除的淋巴母细胞样细胞系（Lymphoblastoid Cell Line，LCL）中呈下调表达的基因（上半部分）、在上述两种敲除细胞系中均呈上调表达的基因（中间部分），以及在两种突变体中表达调控方向相反的基因（下半部分）。针对每个基因，所有匹配至该基因的Affymetrix U133plus2探针组数据均被纳入分析。本研究提供了3B敲除LCL（3BKO-LCL）与wtBAC型LCL之间，以及3AmutB型LCL与野生型（Wild Type，WT）LCL之间的方差分析（Analysis of Variance，ANOVA）p值与表达倍数变化。当p值小于0.001且表达倍数变化大于1.5时，对应的Affymetrix探针编号将以粗体标注；当p值小于0.001或表达倍数变化大于2时，相关数据将以粗体标注。
以斜体标注的基因，在所有EBAN3A突变体与野生型的对比中均达到显著性阈值，但在3AmutB与野生型的对比中未完全满足该阈值。BL31细胞中该基因的表达变化情况将在最后一列中注明。