Microarray analysis of freshly isolated synovial fibroblast subsets in patients with rheumatoid arthritis or osteoarthritis. Microarray analysis of freshly isolated synovial fibroblast subsets in patients with rheumatoid arthritis or osteoarthritis

Transcriptomics of distinct subpopulations of synovial fibroblasts from osteoarthritis and rheumatoid arthritis arthroplasty tissues. Overall design: We gated 7 subsets of synovial fibroblasts by protein surface markers and used microarrays to profile gene expression of cells taken from each gate. This data includes 37 samples from 3 osteoarthritis donors and 3 rheumatoid arthritis donors.

本数据集聚焦骨关节炎（osteoarthritis）与类风湿关节炎（rheumatoid arthritis）患者关节置换（arthroplasty）组织中滑膜成纤维细胞（synovial fibroblasts）的不同亚群，开展转录组学（transcriptomics）分析。实验设计概述：研究团队通过细胞表面蛋白标记的门控分选方法，获取了7类滑膜成纤维细胞亚群，并采用微阵列（microarrays）技术对各亚群的细胞进行基因表达谱检测。本数据集共包含37份样本，分别来自3名骨关节炎供者与3名类风湿关节炎供者。