Lactobacillus rhamnosus Modulates the Neonatal Intestinal Microbiota Changes and Inflammatory Responses to Oral Inoculation with Bacteremia-producing Escherichia coli supplements

Our study aimed to determine the intestinal microbiota modifications following enteral acquisition of neonatal bacteremia-producing E. coli in newborn rats, and the effect of pretreatment with LGG on ameliorating the intestinal microbiota changes and intestinal inflammation produced by ExPEC infection in the neonatal period. We hypothesized that LGG significantly modulates the specific gut microbial populations changes and the inflammatory response elicited by the enteral introduction of septicemia-producing E. coli.

本研究旨在明确新生大鼠经肠内感染可引发新生儿败血症的大肠杆菌后肠道菌群的变化情况，同时探究LGG预处理对改善新生儿期肠外致病性大肠杆菌（Extraintestinal Pathogenic Escherichia coli, ExPEC）感染所致肠道菌群紊乱与肠道炎症的作用。本研究假设，LGG可显著调节经肠内接种产败血症型大肠杆菌所诱导的特异性肠道菌群种群变化及炎症应答。