Profiling and Rewiring Dysfunctional NK cells to Restore Anti-Tumor Activity. Profiling and Rewiring Dysfunctional NK cells to Restore Anti-Tumor Activity

Unraveling the molecular mechanisms of NK cell dysfunction and implications for anti-tumor immunotherapy. Overall design: CD56+CD3neg cells were isolated from the PBMCs of 4 control healthy donors and sorted for Anergic (NKG2A-panKIR-) and Responsive (NKG2A+ panKIR+)

阐明NK细胞功能失调的分子机制及其在抗肿瘤免疫治疗中的潜在意义。实验设计概述：从4名健康对照个体的外周血单个核细胞（PBMCs，Peripheral Blood Mononuclear Cells）中分离CD56阳性CD3阴性细胞，并通过分选获得两类细胞：无能表型（NKG2A-panKIR-）与反应性表型（NKG2A+panKIR+）。