Gene expression of peripheral blood leukocytes in athletes

Probiotics may alter stress sensitivity by modulating the gut-brain axis. The heat-inactivated, enteric-colonizing Lactobacillus gasseri, CP2305 (paraprobiotic CP2305), has been shown to ameliorate psychological stress-related symptoms. This study was designed to reveal the beneficial effects of paraprobiotic CP2305 on top athletes experiencing physical and mental stresses. Forty-nine male university Ekiden runners were randomly assigned to two groups. These athletes consumed a test beverage containing paraprobiotic CP2305 or placebo daily, for 12 weeks. Before and 12 weeks after beverage consumption, the gene expression profiles in peripheral blood leukocytes were assesed by Agilent microarray (SurePrint G3 Human GE 8×60k).

益生菌可通过调控肠-脑轴（gut-brain axis）改变应激敏感性。热灭活肠道定植加氏乳杆菌CP2305（副益生菌CP2305）已被证实可改善心理应激相关症状。本研究旨在探究副益生菌CP2305对同时承受生理与心理应激的顶级运动员的有益作用。49名男性大学驿传赛跑运动员被随机分为两组，受试者每日饮用含有副益生菌CP2305的试验饮品或安慰剂，持续12周。在饮用饮品前及饮用12周后，通过安捷伦微阵列（Agilent microarray，SurePrint G3 Human GE 8×60k）对受试者外周血白细胞中的基因表达谱进行检测分析。