Additional file 1 of Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data

Additional file 1: This file contains the following supplementary tables. Supplemental Table S1a. Gene findings from the UKB analysis, where TBV is the trait of interest. Shown in the table are the p-values. Supplemental Table S1b. Gene findings from the ENIGMA2 analysis, where ICV is the trait of interest. Of note, this is a targeted analysis which only examines the gene findings from the previous UKB analysis. In other words, we were looking for which TBV-associated genes were also significantly associated with ICV. Shown in the table are the p-values. Supplemental Table S2. Among 10 genes discovered in our study, 9 of them (except FAM215B) are significantly associated with TBV in the gene-based association analysis of the original UKB GWAS (Zhao et al.). Supplemental Table S3. Results of enrichment analysis of 10 discovered genes on Gene Ontology Biological Processes. Supplemental Table S4. Results of enrichment analysis of 10 discovered genes on Gene Ontology Molecular Functions.

附加文件1：本文件包含以下补充表格。补充表S1a：基于英国生物库（UKB）分析得到的基因发现，以总脑体积（TBV）为目标性状，表格中展示的为p值。补充表S1b：基于ENIGMA2分析得到的基因发现，以颅内体积（ICV）为目标性状。值得注意的是，本分析为靶向分析，仅针对此前英国生物库分析中的基因发现展开考察，即探究哪些与TBV相关的基因同时与ICV存在显著关联，表格中展示的为p值。补充表S2：本研究发现的10个基因中，有9个（FAM215B除外）在原始英国生物库全基因组关联研究（Genome-Wide Association Study, GWAS）的基于基因的关联分析中与TBV存在显著关联（Zhao等）。补充表S3：针对本次发现的10个基因开展基因本体生物过程（Gene Ontology Biological Processes）富集分析的结果。补充表S4：针对本次发现的10个基因开展基因本体分子功能（Gene Ontology Molecular Functions）富集分析的结果。