Chromatin accessibility dynamics in a model of human forebrain development. Chromatin accessibility dynamics in a model of human forebrain development

In this study, we used a forebrain 3D spheroid model to map chromatin accessibility and gene expression changes throughout a dense time course spanning 20 months of neuronal and glial maturation. Overall design: We generated more than 100 ATAC-seq libraries from iPSC to 20 months in culture. >>>Submitter states that the raw data will be made available through dbGaP due to patient privacy concerns<<<<本研究采用前脑3D球体模型（forebrain 3D spheroid model），对贯穿神经元与胶质细胞成熟全过程、跨度达20个月的密集时间进程中的染色质可及性与基因表达变化进行图谱绘制。整体实验设计：我们从诱导多能干细胞（iPSC）培养阶段起始，共构建了100余个转座酶可及性染色质测序（ATAC-seq）文库，覆盖从诱导多能干细胞培养至20个月的全部样本。>>>提交者声明：鉴于患者隐私相关问题，原始数据将通过基因型与表型数据库（dbGaP）对外公开<<<<