Artesunate overcomes the resistance of basal type of bladder cancer to RC48. Artesunate overcomes the resistance of basal type of bladder cancer to RC48

ERBB2 expression mediates sensitivity of bladder cancer cells to RC48. JAK/STAT3 pathways compensatory activation after exposing RC48. A combination of STAT3 inhibitor-artesunate and RC48 could significantly inhibit basal bladder cancer growth. These findings provided a theoretical foundation for subsequent individualized therapy for MIBC based on the molecular types. Overall design: Comparative gene expression profiling analysis of RNA-seq data for SW780 and RC48-exposed SW780 cells.

人表皮生长因子受体2（ERBB2）的表达可介导膀胱癌细胞对RC48的敏感性。RC48处理膀胱癌细胞后，JAK/STAT3通路会发生代偿性激活。联合应用STAT3抑制剂青蒿琥酯（artesunate）与RC48，可显著抑制基底型膀胱癌细胞的生长。上述研究结果为基于分子分型的肌层浸润性膀胱癌（MIBC）后续个体化治疗提供了理论依据。实验整体设计：对SW780细胞及经RC48处理的SW780细胞的RNA测序（RNA-seq）数据开展比较基因表达谱分析。