Human hepatocytes can give rise to intrahepatic cholangiocarcinomas

To determine the transcriptomic similarity of undifferentiated carcinomas (UDCs) and intrahepatic cholangiocarcinomas (iCCAs) generated from primary human hepatocytes (phHeps) by oncogene expression and transplantation into immue-deficient mice with liver injury to iCCAs and hepatocellular carcinomas (HCCs) resected from patients. Comparison of gene expression profile by RNAseq of phHep-derived UDCs 1-3 and phHep-derived iCCAs 4-12 to patient-derived ICCAs A-C and I-O and patient-derived HCCs D-H.

本数据集旨在明确：通过癌基因诱导表达并移植至肝损伤免疫缺陷小鼠体内、由原代人肝细胞（primary human hepatocytes, phHeps）生成的未分化癌（undifferentiated carcinomas, UDCs）与肝内胆管癌（intrahepatic cholangiocarcinomas, iCCAs），与临床患者切除的肝内胆管癌及肝细胞癌（hepatocellular carcinomas, HCCs）之间的转录组相似性。本研究通过RNA测序（RNA-seq）对以下样本的基因表达谱进行比较分析：原代人肝细胞来源的未分化癌样本1-3、原代人肝细胞来源的肝内胆管癌样本4-12，以及患者来源的肝内胆管癌样本A-C、I-O与患者来源的肝细胞癌样本D-H。