Gene expression profiling of hormone resistant prostate cancer. Homo sapiens

In this study we performed transcriptional profiling of transurethral resections of hormone resistant prostate cancer and compared it with benign prostatic hyperplasia (BPH), untreated localized prostate cancer and hormone sensitive prostate cancer. Keywords: time course; disease state analysis Overall design: Each sample (= Array) is derived from a different patient with the following subsequent disease states: 3x BPH, 7x localized prostate cancer samples, 2 horomone sensitive prostate cancer samples, one locally advanced prostate cancer, 4x hormone resistant prostate cancer early stage and 3x hormone resistant prostate cancer late stage. Platform was Affymetrix

本研究针对激素抵抗型前列腺癌经尿道切除术样本开展了转录组谱分析（transcriptional profiling），并将其与良性前列腺增生（benign prostatic hyperplasia, BPH）、未治疗局限性前列腺癌以及激素敏感型前列腺癌样本进行对比分析。
关键词：时间进程分析；疾病状态分析
整体实验设计：每个样本（即芯片阵列）均来自不同患者，对应下述疾病状态：3例良性前列腺增生（BPH）样本、7例局限性前列腺癌样本、2例激素敏感型前列腺癌样本、1例局部进展期前列腺癌样本、4例早期激素抵抗型前列腺癌样本以及3例晚期激素抵抗型前列腺癌样本。实验平台为Affymetrix。