Visible-Light-Driven Synergistic Se/Fe Catalysis for the Synthesis of 2‑Aminoquinoline Derivatives

A visible-light-driven Se/Fe synergistic catalytic reaction between isocyanides and amines has been developed, employing air as the terminal oxidant. This efficient strategy offers facile access to 2-aminoquinoline scaffolds. The use of cost-effective and readily available Fe(OTf)3 modulates the selenium catalyst’s oxidation state, enhancing the method’s environmental friendliness and practicality. The protocol is further distinguished by its good yields, broad substrate scope, and mild reaction conditions.

本研究开发了一种可见光驱动的异氰化物与胺类之间的硒/铁协同催化反应，以空气作为终端氧化剂。该高效合成策略可便捷构建2-氨基喹啉骨架结构。采用廉价易得的三氟甲磺酸铁(III) (Fe(OTf)3) 调控硒催化剂的氧化态，提升了该方法的环境友好性与实用价值。该反应体系还具备收率优异、底物适用范围广、反应条件温和等显著优势。