表2-6 小肠黏膜形态数据.xls

In sum, oral administration of <em>L. plantarum</em> JL01 and <em>L. rhamnosus</em> GG ATCC53103 to weaned piglets increased apparent nitrogen digestion. We found that dietary supplementation of <em>L. plantarum</em> JL01 and <em>L. rhamnosus</em> GG ATCC53103 improved the gut microbial diversity of weaned piglets. With the help of functional genes encoded by intestinal dominant bacteria, the production of dominant metabolites L-tryptophan 3-Phosphonooxypyruvate, cis-Aconitate and Carbamoyl phosphate is promoted, and these metabolites promote the TCA cycle in different ways, which may lead to the increase of AKG, and then play a positive regulatory role in skeletal muscle protein deposition. Moreover, L-tryptophan has a positive regulatory effect on nitrogen metabolism. This finding further highlights the importance of gut microbiota for nitrogen metabolism and demonstrates an effect of <em>L. plantarum</em> JL01 and <em>L. rhamnosus</em> GG ATCC53103 to promote nitrogen metabolism in weaned piglets.

综上所述，给断奶仔猪灌服植物乳杆菌（L. plantarum）JL01与鼠李糖乳杆菌（L. rhamnosus）GG ATCC53103，可提升其表观氮消化率。本研究发现，在日粮中添加植物乳杆菌JL01与鼠李糖乳杆菌GG ATCC53103，可改善断奶仔猪的肠道微生物多样性。借助肠道优势菌群编码的功能基因，优势代谢物L-色氨酸、3-磷酸羟基丙酮酸、顺乌头酸及氨甲酰磷酸的生成得以促进；上述代谢物可通过不同途径调控三羧酸（TCA）循环，进而可能促使α-酮戊二酸（AKG）水平升高，最终对骨骼肌蛋白质沉积发挥正向调控作用。此外，L-色氨酸对氮代谢亦具有正向调控效果。本研究结果进一步凸显了肠道菌群对氮代谢的重要性，并证实植物乳杆菌JL01与鼠李糖乳杆菌GG ATCC53103可促进断奶仔猪的氮代谢。