Austrian Crystallographic Diffraction Consortium

The Austrian Crystallographic Diffraction Consortium (ACDC) BAG aims at supporting several macromolecular structural biology groups across Austria (in total 20 research groups at 9 institutions in 4 cities). We employ mainly the technique of X-ray crystallography to characterize macromolecular biological complexes, but also solution scattering approaches are frequently used to characterize dynamic assemblies. Approval of this BAG will be essential for researchers in all our groups to carry out their structural studies on various health-related and basic research-oriented topics, which are targeted at characterizing large molecular assemblies or proteins currently under-represented in the PDB, including membrane proteins. Corresponding high-resolution diffraction data are only obtainable through the use of synchrotron radiation sources. Thus regular synchrotron access is highly desirable to maintain a competitive advantage in our individual research fields.

奥地利晶体衍射联盟（Austrian Crystallographic Diffraction Consortium，ACDC）BAG旨在支持奥地利境内多个生物大分子结构生物学研究团队（共计4个城市9所机构的20个研究组）。我们主要采用X射线晶体学（X-ray crystallography）技术表征生物大分子复合物，同时也常使用溶液散射方法（solution scattering approaches）研究动态组装体。该BAG的获批对于我们所有团队的研究人员开展各类健康相关及基础研究主题的结构研究至关重要，这些研究旨在表征目前在蛋白质数据库（Protein Data Bank，PDB）中代表性不足的大型分子组装体或蛋白质，包括膜蛋白（membrane proteins）。相应的高分辨率衍射数据仅能通过同步辐射源（synchrotron radiation sources）获取。因此，为在各自研究领域保持竞争优势，定期使用同步辐射设施是非常必要的。