Model size after each reconstruction step.

aOthers include proteins involve in complex relationships, e.g. multiple proteins act as protein complex which is one of the isozymes for any specific reaction.bSpontaneous reactions are those without any enzyme as well as gene association.cUnique metabolites irrespective of their compartmental location.

a. 其余类别包含参与复杂相互作用关系的蛋白质，例如：多个蛋白质共同组装形成蛋白质复合物（protein complex），该复合物可作为任一特定催化反应的同工酶（isozyme）之一。
b. 自发反应指无需任何酶参与，也无基因关联的反应。
c. 不考虑细胞区室定位的独特代谢物（metabolite）。