Epigenome analysis of irradiated and non-irradiated breast tumor tissue samples and normal controls. Homo sapiens

Genome wide DNA methylation profiling of irradiated and non-irradiated breast tumor samples and normal control tissue. The Illumina Infinium 27k Human DNA methylation Beadchip, Genome Build 36 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in breast tumor samples. Samples included 20 non-irradiated tumor samples, 19 irradiated tumor samples and 9 normal controls. Overall design: Bisulphite converted DNA from the 48 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

本数据集针对经辐照与未辐照的乳腺肿瘤样本及正常对照组织开展全基因组DNA甲基化谱分析。本研究采用Illumina Infinium 27k人类DNA甲基化芯片（Illumina Infinium 27k Human DNA methylation Beadchip）结合基因组组装版本36（Genome Build 36），对乳腺肿瘤样本中约27000个CpG位点（CpG）的DNA甲基化谱进行检测。共纳入48份样本，包括20例未辐照肿瘤样本、19例辐照肿瘤样本及9例正常对照样本。实验整体设计如下：将48份样本经亚硫酸氢盐转化后的DNA与Illumina Infinium 27k人类甲基化芯片v1.2进行杂交。