DataSheet1_Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode.docx

An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide–TiO2–Au nanocomposite-modified glassy carbon electrode (rGO–TiO2–Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to confirm morphology, structure, and composition properties of the rGO–TiO2–Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO–TiO2–Au/GCE for ACV. As a result, rGO–TiO2–Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µl. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1–100 µM, and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results.

本研究采用还原氧化石墨烯-二氧化钛-金纳米复合材料修饰玻碳电极（rGO–TiO2–Au/GCE），构建了一款可灵敏检测阿昔洛韦（acyclovir, ACV）的电化学传感器。采用透射电子显微镜、X射线衍射仪及X射线光电子能谱对rGO–TiO2–Au纳米复合材料的形貌、结构与组成特性进行了表征。通过循环伏安法与线性扫描伏安法评估了rGO–TiO2–Au/GCE对阿昔洛韦的分析性能。结果表明，在pH 6.0的磷酸盐（PB）缓冲溶液中、开路条件下富集80 s且修饰剂用量为7 μl的最优条件下，rGO–TiO2–Au/GCE对阿昔洛韦的氧化响应效果最佳。阿昔洛韦的氧化峰电流在1~100 μM浓度范围内与其浓度呈良好线性关系，检出限（S/N=3）为0.3 μM。对片剂样品中阿昔洛韦浓度的测定结果同样令人满意。