A bioinformatics approach reveals novel mechanisms of the OVOL transcription factors in the regulation of epithelial-mesenchymal cell programming and cancer progression

We find significant evidence of the OVOL, AP1, STAT1, STAT3, and NFKB1 TFs having important roles in MET. We prioritize known gene/drug targets for follow-up in the clinic, and show that the AP1/MYC TF pair is a strong candidate for intervention. Examination of the effects of OVOL1 and OVOL2 overexpression common to prostate cancer and breast cancer models.

我们找到了确凿证据，证实OVOL、AP1、STAT1、STAT3与NFKB1转录因子（Transcription Factors, TFs）在MET中发挥关键调控作用。我们优先遴选已知基因与药物靶点用于临床后续研究，并证明AP1/MYC转录因子对是极具潜力的干预候选靶点。我们针对前列腺癌与乳腺癌模型中共有的OVOL1及OVOL2过表达的效应开展了系统检测与分析。