Transcriptional profiling reveals differential changes in the expression of oxytocin and CARTpt mRNAs in the nucleus accumbens and dorsal striatum of rats (striatum)

Methamphetamine addiction is mimicked in rats that self-administer the drug and accelerate their intake when given long access to it. Self-administration (SA) models do not include adverse consequences that are necessary to reach a diagnosis of addiction in humans. Here, we studied transcriptional consequences of methamphetamine SA and repeated foot-shocks in rat brain.甲基苯丙胺（methamphetamine）成瘾可通过自主摄取该药物的大鼠进行模拟，当大鼠获得长期药物摄取机会时，其药物摄入速率会加快。自主摄取（self-administration, SA）模型并未涵盖人类成瘾诊断所必需的不良后果。本研究以大鼠脑组织为研究对象，探究了甲基苯丙胺自主摄取与反复足部电击所产生的转录组学效应。