Table1_Discussion on operation: To compare the curative effect of PMT and CDT in the treatment of middle and high risk stratified APE and the clinical application value of serum BNP, TnI and plasma DFR levelse.xls

ObjectiveTo compare the efficacy of Percutaneous mechanical thrombectomy (PMT) and Catheter directed thrombolysis (CDT) in the treatment of patients with moderate and high-risk ape and explore the clinical application value of biomarkers in the treatment of moderate and high-risk ape.MethodA total of 84 patients with ape were selected from the Department of vascular surgery of the Second Affiliated Hospital of Shandong First Medical University and the Department of vascular surgery of Shanghai Ninth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine. According to the relevant guidelines, they were divided into high-risk and medium-risk groups, including PMT groups (35 cases) and CDT groups (49 cases). To detect the changes of serum B-type brain natriuretic peptide (BNP),Troponin I (TnI) and plasma D-dimer/fibrinogen ratio (DFR) levels in different risk stratification before and after PMT and CDT, the correlation and diagnostic value of each index, and compare the thrombus clearance rate, pulmonary artery pressure, average dosage of urokinase, effective thrombolytic time, average hospitalization time and complications of PMT and CDT.ResultUnder different treatment methods and risk stratification, there was no statistically significant difference in the clinical data of patients at general baseline;The preoperative BNP, TnI and DFR levels of PMT and CDT in the middle and high risk stratification were significantly lower than those in the other groups (P

研究目标：旨在比较经皮机械血栓切除术（PMT）与导管定向溶栓术（CDT）在治疗中高风险急性肺栓塞患者中的疗效，并探讨生物标志物在中高风险急性肺栓塞治疗中的临床应用价值。研究方法：从山东第一医科大学第二附属医院及上海交通大学医学院附属第九人民医院血管外科选取84例急性肺栓塞患者，依据相关指南将其分为高危与中危组，包括PMT组（35例）和CDT组（49例）。为检测PMT和CDT前后不同风险分层血清B型脑钠肽（BNP）、肌钙蛋白I（TnI）及血浆D-二聚体/纤维蛋白原比（DFR）水平的变化，以及各指标的相关性和诊断价值，并比较PMT和CDT的血栓清除率、肺动脉压、尿激酶平均用量、有效溶栓时间、平均住院时间及并发症。研究结果：在不同治疗方法及风险分层下，患者的一般基线临床数据无统计学差异；在中等及高危分层中，PMT和CDT的术前BNP、TnI及DFR水平显著低于其他组（P