MOESM1 of An epigenome-wide association study of sex-specific chronological ageing

Additional file 1: Tables S1-S10: Top 1000 autosomal probe associations for chronological age present in both discovery and replication cohorts, using the linear regression model, ranked by discovery P-value. Table headers correspond to Limma TopTable outputs - Table S1. Top 1000 X-linked probe associations for chronological age present in the discovery and replication cohorts, using the linear regression model, ranked by discovery P-value. Table headers correspond to Limma TopTable outputs - Table S2. Top 1000 autosomal probe associations for sex present in both discovery and replication cohorts, using the linear regression model, ranked by discovery P-value. Table headers correspond to Limma TopTable outputs - Table S3. Top 1000 autosomal probe associations for the age-by-sex interaction present in both discovery and replication cohorts, using the linear regression method, ranked by discovery P-value. Table headers correspond to Limma TopTable outputs - Table S4. Top 1000 X-linked probe associations for the age-by-sex interaction present in both discovery and replication cohorts, using the linear regression approach, ranked by discovery P-value. Table headers correspond to Limma TopTable outputs - Table S5. Epigenome-wide significant sites associated with the age-by-sex interaction with concordant effects in the discovery and replication cohorts identified using the conservative mixed-modelling approach - Table S6. GWAS catalogue outputs within 1 Mb of age-by-sex-associated CpGs - Table S7. ARIES mQTLdb output for query containing age-by-sex-associated CpGs - Table S8. KEGG pathway enrichment output for age-by-sex-associated sites - Table S9. GO Term enrichment output for age-by-sex-associated sites - Table S10.

附加文件1：表S1至S10：
表S1：在发现队列与重复队列中均存在、采用线性回归模型构建、按发现组P值排序的与实足年龄相关的前1000个常染色体探针关联结果，表表头对应Limma TopTable输出格式；
表S2：在发现队列与重复队列中均存在、采用线性回归模型构建、按发现组P值排序的与实足年龄相关的前1000个X连锁探针关联结果，表表头对应Limma TopTable输出格式；
表S3：在发现队列与重复队列中均存在、采用线性回归模型构建、按发现组P值排序的与性别相关的前1000个常染色体探针关联结果，表表头对应Limma TopTable输出格式；
表S4：在发现队列与重复队列中均存在、采用线性回归方法构建、按发现组P值排序的与年龄-性别交互作用相关的前1000个常染色体探针关联结果，表表头对应Limma TopTable输出格式；
表S5：在发现队列与重复队列中均存在、采用线性回归方法构建、按发现组P值排序的与年龄-性别交互作用相关的前1000个X连锁探针关联结果，表表头对应Limma TopTable输出格式；
表S6：采用保守混合建模方法，在发现队列与重复队列中鉴定得到的、效应一致的全表观基因组显著性年龄-性别交互作用相关位点；
表S7：位于年龄-性别交互作用相关CpG位点上下游1 Mb范围内的全基因组关联研究（Genome-Wide Association Study, GWAS）目录输出结果；
表S8：针对年龄-性别交互作用相关CpG位点的查询结果，来自ARIES甲基化数量性状位点数据库（methylation Quantitative Trait Locus database, mQTLdb）；
表S9：年龄-性别交互作用相关位点的京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes, KEGG）通路富集分析结果；
表S10：年龄-性别交互作用相关位点的基因本体（Gene Ontology, GO）术语富集分析结果。