Differences in subcutaneous adipose tissue gene expression between obese African Americans and Hispanic Youths. Homo sapiens

Obesity is a major risk factor for several chronic diseases including diabetes, fatty liver disease and cancer. Despite similar propensities for obesity, Hispanics and African Americans exhibit unique and distinct differences in obesity related outcomes such as greater risk of, obesity-related cancers in AA and non alcoholic fatty liver disease (NAFLD) in Hispanics. This study was aimed to determine whether differences in subcutaneous adipose tissue (SAT) gene expression in obese, Hispanic and AA young adults might explain ethnic differences in obesity-related phenotypes. Overall design: cross-sectional study design to compare subcutaneous adipose tissue gene expression profiles of 19 Hispanic and 17 African American young adults

肥胖是糖尿病、脂肪肝病及癌症等多种慢性病的主要危险因素。尽管西班牙裔与非裔美国人（African Americans）群体的肥胖易感性相近，但二者在肥胖相关转归上存在独特且显著的差异：非裔美国人（AA）罹患肥胖相关癌症的风险更高，而西班牙裔则更易患非酒精性脂肪肝病（non alcoholic fatty liver disease, NAFLD）。本研究旨在探究肥胖的西班牙裔与非裔美国年轻成年人的皮下脂肪组织（subcutaneous adipose tissue, SAT）基因表达差异，能否解释肥胖相关表型的种族差异。总体实验设计：本研究采用横断面研究设计，对比19名西班牙裔与17名非裔美国年轻成年人的皮下脂肪组织基因表达谱。