Human Cytomegalovirus Open Reading Frame TRL11/IRL11 Encodes an Immunoglobulin G Fc-Binding Protein

Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.

多种疱疹病毒可编码Fc受体（Fc receptor），此类受体或可在体内阻断抗体介导的病毒清除过程。人类巨细胞病毒（Human cytomegalovirus，HCMV）在感染宿主细胞后可诱导产生Fc结合活性，但编码该Fc结合蛋白的基因至今尚未被鉴定。本研究证实，HCMV AD169株的开放阅读框（open reading frame，ORF）TRL11及其相同拷贝IRL11，能够编码一种具备IgG Fc结合能力的I型膜糖蛋白（type I membrane glycoprotein）。