Table_3_Impact of Succinylcholine vs. Rocuronium on Apnea Duration for Rapid Sequence Induction: A Prospective Cohort Study.docx

ObjectiveThe present study aimed to evaluate the impact of 1.5 mg/kg succinylcholine or 1.2 mg/kg rocuronium, vs. 1.0 mg/kg succinylcholine on apnea duration in patients underwent rapid sequence induction (RSI).
MethodsThis prospective cohort study was conducted in the Department of Anesthesiology in Shanghai General Hospital from July 2020 to November 2020. Apnea duration was defined as the time from apnea prompted by the PETCO2 waveform to the time the point of oxygen saturation declined to 90% (T90) and 95% (T95) after succinylcholine or rocuronium administration. The primary outcome included T90 and T95 changes in 1.5 mg/kg vs. 1.0 mg/kg succinylcholine groups and 1.5 mg/kg succinylcholine vs. 1.2 mg/kg rocuronium groups.
ResultsA total of 265 participants were subjected for analysis. The succinylcholine (1.0 mg/kg) group had a significantly longer T90 (50.72, 95% confidence interval [CI, 7.60, 94.38], P = 0.015) and T95 (48.09, 95% CI [7.11, 89.07], P = 0.012) than the succinylcholine (1.5 mg/kg) group. In addition, significantly longer T90 (56.84, 95% CI [16.24, 97.44], P = 0.003) and T95 (50.57, 95% CI [12.58, 88.57], P = 0.003) were observed in the rocuronium (1.2 mg/kg) group than those in the succinylcholine (1.5 mg/kg) group. No severe side events were observed during the operation.
ConclusionRocuronium and the lower dose of succinylcholine may be recommended to patients underwent RSI.

研究目的
本研究旨在评估1.5mg/kg琥珀胆碱、1.2mg/kg罗库溴铵相较于1.0mg/kg琥珀胆碱，对接受快速顺序诱导（rapid sequence induction, RSI）患者呼吸暂停时长的影响。

研究方法
本前瞻性队列研究于2020年7月至2020年11月在上海总医院麻醉科开展。呼吸暂停时长定义为：给予琥珀胆碱或罗库溴铵后，从呼气末二氧化碳（PETCO₂）波形提示呼吸暂停发作开始，至血氧饱和度降至90%（记为T90）及95%（记为T95）的时长。主要结局指标包括1.5mg/kg琥珀胆碱组与1.0mg/kg琥珀胆碱组，以及1.5mg/kg琥珀胆碱组与1.2mg/kg罗库溴铵组的T90与T95变化情况。

研究结果
本研究共纳入265例患者进行数据分析。1.0mg/kg琥珀胆碱组的T90（50.72，95%置信区间[CI, 7.60, 94.38]，P=0.015）与T95（48.09，95%置信区间[CI, 7.11, 89.07]，P=0.012）均显著长于1.5mg/kg琥珀胆碱组。此外，1.2mg/kg罗库溴铵组的T90（56.84，95%置信区间[CI, 16.24, 97.44]，P=0.003）与T95（50.57，95%置信区间[CI, 12.58, 88.57]，P=0.003）均显著长于1.5mg/kg琥珀胆碱组。术中未观察到严重不良事件。

研究结论
对于接受快速顺序诱导的患者，推荐使用罗库溴铵及低剂量琥珀胆碱。