Bulk RNA-seq analysis of the striatum in G2019S LRRK2 knockin mice under a specialized diet

This Zenodo deposit contains a publicly available description of the Dataset: Title: "Bulk RNA-seq analysis of the striatum in G2019S LRRK2 knockin mice under a specialized diet". Description: G2019S LRRK2 knockin mice and their wild-type littermates were maintained on a normal chow diet (23.7% kcal from fat) for the first 11 months of life. At that time, animals were randomly assigned to either a high-fat diet group (60% kcal from fat) or a control diet group (10% kcal from fat). Mice remained on their respective diets for an additional five months. At 16 months of age, striatal tissue was collected for bulk RNA-seq analysis. Each experimental group contained biological replicates (n = 4 per group). This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual. This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF). This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset本Zenodo存档公开提供了如下数据集的说明： 标题："特殊饮食干预下G2019S LRRK2敲入小鼠（G2019S LRRK2 knockin mice）纹状体（striatum）的批量RNA测序（Bulk RNA-seq）分析" 数据集说明：G2019S LRRK2敲入小鼠及其野生型同窝对照小鼠在生命前11个月均饲喂普通维持饲料（脂肪供能占比23.7%）。饲养至第11个月时，将所有小鼠随机分为高脂饮食组（脂肪供能占比60%）与对照饮食组（脂肪供能占比10%）。两组小鼠继续饲喂对应饮食共计5个月。小鼠饲养至16月龄时，采集其纹状体组织用于批量RNA测序分析。每个实验组均设置生物学重复（每组n=4）。 本数据集通过ASAP CRN云平台（ASAP CRN Cloud，cloud.parkinsonsroadmap.org）向科研人员开放。获取数据集访问权限的操作指南可参阅用户手册。 本研究由帕金森病研究对齐科学协作网络（Aligning Science Across Parkinson's Collaborative Research Network，简称ASAP CRN）通过迈克尔·J·福克斯帕金森病研究基金会（Michael J. Fox Foundation for Parkinson's Research，简称MJFF）资助。 本Zenodo存档由ASAP CRN云平台工作人员代表数据集作者创建，旨在为CRN云平台数据集提供可引用的学术存档资源。