Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a methylisoquinoline Fasudil-derivative

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a methylisoquinoline Fasudil-derivative Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1,4-diazepan-1-ylsulfonyl)-4-methyl-isoquinoline, cAMP-dependent protein kinase catalytic subunit alpha, ... Authors: Wienen-Schmidt, B, Heine, A, Klebe, G. Deposit date: 2016-10-26 Release date: 2018-06-06 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.367 Å) Cite: Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with differently methylated Fasudil-derived ligands To be Published

cAMP依赖性蛋白激酶（cAMP-dependent Protein Kinase, PKA）与甲基异喹啉类法舒地尔（Fasudil）衍生物形成复合物的共晶结构。配体描述：(4S)-2-甲基-2,4-戊二醇、5-(1,4-二氮杂环庚烷-1-基磺酰基)-4-甲基异喹啉、cAMP依赖性蛋白激酶催化亚基α…… 作者：Wienen-Schmidt B、Heine A、Klebe G。提交日期：2016-10-26；发布日期：2018-06-06；最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.367埃（Å）。引用信息：《cAMP依赖性蛋白激酶（PKA）与不同甲基化法舒地尔衍生配体的共晶结构》，待发表。