The complex structure of Rv3378c-Y51FY90F with substrate, TPP

The complex structure of Rv3378c-Y51FY90F with substrate, TPP Descriptor: (2E)-3-methyl-5-[(1R,2S,8aS)-1,2,5,5-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-1-yl]pent-2-en-1-yl trihydrogen diphosphate, Diterpene synthase, PHOSPHATE ION Authors: Chan, H.C, Feng, X, Ko, T.P, Huang, C.H, Hu, Y, Zheng, Y, Bogue, S, Nakano, C, Hoshino, T, Zhang, L, Lv, P, Liu, W, Crick, D.C, Liang, P.H, Wang, A.H, Oldfield, E, Guo, R.T. Deposit date: 2013-05-20 Release date: 2014-02-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J.Am.Chem.Soc., 136, 2014

携带底物的Rv3378c-Y51FY90F复合物结构，TPP标识符：(2E)-3-甲基-5-[(1R,2S,8aS)-1,2,5,5-四甲基-1,2,3,5,6,7,8,8a-八氢萘-1-基]戊-2-烯-1-基三氢二磷酸酯；该复合物涉及双萜合酶（Diterpene synthase）与磷酸根离子（PHOSPHATE ION）。作者：Chan, H.C、Feng, X、Ko, T.P、Huang, C.H、Hu, Y、Zheng, Y、Bogue, S、Nakano, C、Hoshino, T、Zhang, L、Lv, P、Liu, W、Crick, D.C、Liang, P.H、Wang, A.H、Oldfield, E、Guo, R.T。存储日期：2013-05-20；发布日期：2014-02-26；最后修改日期：2023-11-08。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4埃（2.4 Å）。引用文献：《结核分枝杆菌来源的结核香芹醇合酶与癸异戊烯二磷酸合酶的结构及其抑制作用》，刊载于《美国化学会志》（J.Am.Chem.Soc.），136卷，2014年。