Pellucid marginal degeneration: postponing penetrating keratoplasty for over a decade

Abstract Pellucid marginal degeneration (PMD) treatment can be challenging in moderate to advanced cases and penetrating keratoplasty should be avoided due to high risk of complications, such as graft rejection. We report a case of a 30-year-old female patient with PMD that was referred to our service with bilateral low visual acuity, worse in her right eye and contact lenses intolerance. We performed a corneal crescentic lamellar wedge resection that resulted in good useful vision and postponed the keratoplasty for eighteen years.

摘要：透明边缘变性（Pellucid marginal degeneration, PMD）在中至重度病例的治疗中颇具挑战，且由于移植排斥反应（graft rejection）等并发症风险较高，应避免施行穿透性角膜移植术（penetrating keratoplasty）。本文报告1例30岁女性PMD患者，该患者因双眼视力低下（右眼视力更差）且无法耐受角膜接触镜转诊至我科。我们为其实施了角膜新月形板层楔状切除术（corneal crescentic lamellar wedge resection），术后患者获得了良好的有效视力，且将角膜移植术的实施推迟了18年。