Gene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]

Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggressor mice and the length of rest time after the exposure. The conditions included were short exposure-short rest (T5R1-T indicates the number of days of trauma exposure; R indicates the number of days of rest after exposure), short exposure-long rest (T5R10), long exposure-short rest (T10R1) and long exposure-long rest (T10R42)

本研究采用创伤后应激障碍（PTSD）小鼠模型，探究了经胁迫威慑暴露后的心脏组织纵向转录组学变化。我们开展了初始研究（研究I），设置了四种实验条件，通过调整从属小鼠暴露于攻击小鼠的时长，以及暴露后的休息时长来调控变量。本次涵盖的实验条件包括：短暴露-短休息（T5R1，其中T代表创伤暴露天数，R代表暴露后休息天数）、短暴露-长休息（T5R10）、长暴露-短休息（T10R1）以及长暴露-长休息（T10R42）。