Gastric cancer subtyping (Singapore Patient Cohort, batch B)

Genome-wide mRNA expression profiles of 56 primary gastric tumors from the Singapore patient cohort, batch B. Like many cancers, gastric adenocarcinomas (gastric cancers) show considerable heterogeneity between patients. Thus, there is intense interest in using gene expression profiles to discover subtypes of gastric cancers with particular biological properties or therapeutic vulnerabilities. Identification of such subtypes could generate insights into the mechanisms of cancer progression or lay the foundation for personalized treatments. Here we report a robust gene-expression-based clustering of a large collection of gastric adenocarcinomas (with GSE15459) from Singaporean patients. Profiling of 56 primary gastric tumors on Affymetrix GeneChip Human Genome U133 Plus 2.0 Array. All tumors were collected with approvals from the National Cancer Centre, Singapore; the Research Ethics Review Committee; and signed patient informed consent.

新加坡患者队列B批次的56例原发性胃肿瘤的全基因组mRNA表达谱。与多数癌症类似，胃腺癌（胃癌）在患者间存在显著异质性。因此，学界高度关注利用基因表达谱挖掘具有特定生物学特性或治疗脆弱性的胃癌亚型。此类亚型的鉴定可为解析癌症进展机制提供新见解，亦可为个性化治疗奠定基础。本研究针对新加坡患者的大量胃腺癌样本（含GSE15459数据集）开展了基于基因表达的稳健聚类分析。本研究使用Affymetrix GeneChip Human Genome U133 Plus 2.0 Array芯片对56例原发性胃肿瘤进行了表达谱检测。所有肿瘤样本的采集均获得新加坡国家癌症中心、研究伦理审查委员会的批准，并已获取患者签署的知情同意书。