Independent, genome-wide significant (GWS) SNPs from meta-analysis of sex-stratified MCP GWASs.

Genomic Locus = genomic risk locus context of SNP with multiple independent GWS SNPs present at some of the 46 loci, rsID = SNP rsID identifier, Position = genomic position (chromosome: base-pair start position), Meta p = p value for association from the GWAS meta-analysis, Direction = direction of effect in female MCP and male MCP GWASs, respectively (+ if association beta value for effect allele > 0,—if 2 = effect size heterogeneity estimate, I2 p = p value for heterogeneity estimate, Symbol = ANNOVAR gene annotation for variant (N/A, no gene annotation in ANNOVAR). Significant (unadjusted) heterogeneity I2 p values (I2 p

Genomic Locus（基因组位点）：指携带单核苷酸多态性（Single Nucleotide Polymorphism, SNP）的基因组风险位点，46个位点中的部分位点存在多个独立的全基因组显著（Genome-Wide Significant, GWS）SNP；rsID（SNP的rs标识符）：SNP的rsID识别编号；Position（基因组位置）：基因组位置，格式为「染色体: 碱基对起始位置」；Meta p（荟萃分析关联p值）：全基因组关联研究（Genome-Wide Association Study, GWAS）荟萃分析中得到的关联检验p值；Direction（效应方向）：分别对应女性MCP与男性MCP的GWAS中的效应方向，若效应等位基因的关联β值大于0则记为+，反之记为-；2：效应量异质性估计值；I2 p（异质性检验p值）：异质性估计对应的p值；Symbol（基因注释符号）：变异的ANNOVAR基因注释结果，若无对应基因注释则记为N/A；显著（未校正）的异质性I2 p值（I2 p