Additional file 5: Table S5. of Gene expression and adaptive noncoding changes during human evolution

Functional correlations between differential expression overall and noncoding adaptation. All MSigDB collections we considered are listed except for C2:CP:BioCarta, in which no gene set contained at least 50 genes analyzed in a previous study of adaptive noncoding changes. # sets is the number of gene sets we considered in the collection. rr is the rank correlation between rank-biserial correlations for enrichment with differential expression and rank-biserial correlations for enrichment with noncoding adaptation. p(rr) is the one-tailed p-value of rr via permutation test with 10,000 permutations; collections are ordered by increasing p(rr), which reflects rr, # sets, and patterns of overlap among gene sets in the collection. (XLSX 63 kb)

整体差异表达与非编码适应性间的功能关联。本研究纳入的所有分子特征数据库（MSigDB）集合均已列出，仅排除了C2:CP:BioCarta集合——该集合中不存在包含至少50个既往非编码适应性变化研究中所分析基因的基因集。# sets指该集合中我们纳入的基因集数量。rr为差异表达富集的等级二列相关系数与非编码适应性富集的等级二列相关系数之间的等级相关系数。p(rr)为通过10000次置换检验得到的rr的单侧p值；各集合按p(rr)递增的顺序排列，该排序同时反映了rr、# sets以及该集合内基因集间的重叠模式。（XLSX格式，63 KB）