Gut microbiota and clinical manifestations in Thai pediatric patients with attention deficit hyperactivity disorder

Attention-deficit hyperactivity disorder (ADHD) was the most common childhood-onset neurodevelopmental and behavioral disorder. Several studies suggested that gut microbiota played an essential role in the bidirectional communication between the gut and the brain via neurotransmitter systems. Gut dysbiosis might be the link to ADHD's pathophysiology. This study aimed to identify gut microbiota profile in treatment-naive Thai children with ADHD and age- and sex-matched healthy controls as a comparative cross-sectional study.

注意缺陷多动障碍（Attention-deficit hyperactivity disorder，ADHD）是最为常见的儿童起病型神经发育与行为障碍。多项研究表明，肠道菌群可通过神经递质系统在肠道与大脑之间实现双向通讯，并发挥关键作用。肠道菌群失调可能是连接注意缺陷多动障碍病理生理机制的重要环节。本研究作为一项对比性横断面研究，旨在明确未接受过治疗的泰国注意缺陷多动障碍患儿，以及与其年龄、性别匹配的健康对照者的肠道菌群特征。