Detection of HIV-1 infections in blood donors during the pre-seroconversion window period in São Paulo, Brazil

Abstract By decreasing the pre-seroconversion window period, nucleic acid testing (NAT) has improved the safety of blood products and reduced the risk of transfusion-transmitted infections. Between 2011 and 2017, NAT determinations for approximately 898,202 donations were performed at Fundação Pró-Sangue/Hemocentro de São Paulo (FPS-HSP). Three seronegative HIV-viremic donations were detected. The NAT yield rate per million donations was 3.34 for HIV, and the acute HIV-1 infections detected are described, followed by a brief review of the situation in Brazil.

摘要：通过缩短血清转换前窗口期，核酸检测（nucleic acid testing, NAT）提升了血液制品的安全性，降低了输血传播感染的风险。2011年至2017年间，圣保罗血液中心（Fundação Pró-Sangue/Hemocentro de São Paulo, FPS-HSP）对约898202份献血样本开展了核酸检测，共检出3例血清学阴性但HIV病毒血症的献血样本。每百万份献血样本的HIV核酸检测检出率为3.34，本文对检出的急性HIV-1感染病例进行了描述，并简要回顾了巴西当前的相关情况。