THE ROLE OF ANGIOGENESIS AND HISTOGENESIS IN WOUND HEALING AND MODERN THERAPEUTIC APPROACHES

Wound healing is a multi-stage and complex biological process in which histogenesis and angiogenesis play a central role. This study is dedicated to analyzing the histological stages of wound healing, the mechanisms of angiogenesis and histogenesis in this process, as well as modern therapeutic approaches. A literature review method was employed, and relevant experimental and clinical data were synthesized. The results show that the four main stages of wound healing — hemostasis, inflammation, proliferation, and maturation — are closely associated with the processes of histogenesis and angiogenesis. The growth of new blood vessels (neoangiogenesis) and tissue restoration (histogenesis) occur in a coordinated manner. These mechanisms observed in skin wound healing are also compared with myocardial tissue regeneration (Rozibayev et al., 2025a). Modern therapeutic strategies, including the use of growth factors, ROS-targeted nanotherapeutic systems, and matrix scaffolds, may significantly enhance wound healing efficacy. The author concludes that combined therapeutic approaches that specifically stimulate angiogenesis and histogenesis deserve attention as a new paradigm in wound healing.

伤口愈合是一类多阶段的复杂生物学过程，其中组织发生(histogenesis)与血管生成(angiogenesis)发挥核心作用。本研究旨在解析伤口愈合的组织学阶段、该过程中血管生成与组织发生的调控机制，以及现代治疗策略。研究采用文献综述法，整合了相关实验与临床数据。结果表明，伤口愈合的四大核心阶段——止血(hemostasis)、炎症(inflammation)、增殖(proliferation)与成熟(maturation)——均与组织发生和血管生成过程密切相关。新生血管生长（新生血管生成，neoangiogenesis）与组织修复（组织发生，histogenesis）以协同方式有序进行。本研究还将皮肤伤口愈合中观测到的上述机制与心肌组织再生进行了对比（Rozibayev等，2025a）。现代治疗策略包括生长因子的应用、靶向活性氧(ROS)的纳米治疗系统以及基质支架，可显著提升伤口愈合的效能。研究者总结指出，能够特异性刺激血管生成与组织发生的联合治疗方案，有望成为伤口愈合领域的全新治疗范式，值得重点关注。