mRNA expression profile in a murine model of hyperoxia-induced bronchopulmonary dysplasia

We performed miRNA and mRNA profiling at postnatal day 14 and day 29 to compare hyperoxia-induced bronchopulmonary dysplasia and wild type. We built potential miRNA-mRNA interaction networks specific to brochopulmonary dysplasia. Replicated time course of mouse lung development at 2 time points (P14, P29). Three replicates per time point for bronchopulmonary dysplasia induced by hyperoxia mouse lung, and two replicates per time point for wild type mouse lung. This dataset represents the mRNA expression profiling component of the study.

本研究于出生后第14天（P14）与出生后第29天（P29）开展微小RNA（microRNA, miRNA）与信使RNA（messenger RNA, mRNA）的表达谱分析，以对比高氧诱导的支气管肺发育不良（hyperoxia-induced bronchopulmonary dysplasia）模型与野生型（wild type）样本。本研究构建了针对支气管肺发育不良的特异性潜在miRNA-mRNA互作网络。本研究的采样覆盖小鼠肺发育的两个时间点（P14、P29），且设置了生物学重复：高氧诱导支气管肺发育不良的小鼠肺组织每个时间点设置3次生物学重复，野生型小鼠肺组织每个时间点设置2次生物学重复。本数据集为本研究的信使RNA表达谱分析组分。