Chromatin state of distal genomic intervals.

We used cell type specific chromatin state data (Broad ChromHMM) [23] to identify the proportion of the high-scoring AP-1 motif containing distal genomic intervals that overlap with ENCODE defined enhancers. We analyzed the overlaps for the HUVEC, K562, and GM12878 cell lines (rows) and relate them to the AP-1+ motif containing genomic intervals.本研究采用细胞类型特异性染色质状态数据（Broad ChromHMM）[23]，鉴定包含高评分AP-1基序的远端基因组区间与ENCODE定义增强子的重叠比例。我们针对以HUVEC、K562及GM12878细胞系为行的数据集开展重叠分析，并将该分析结果与包含AP-1+基序的基因组区间进行关联。