Resistance profile of ISM-adapted cell lines and the parental cell line Tb427WT.

EC50 values are given as mean of at least 5 independent determinations and SEM. The resistance factor (RF) is the ratio of the EC50 values of the adapted strain and the wild-type control. Statistical significance was determined using a two-tailed unpaired t-test.

半数效应浓度（EC50）值以至少5次独立测定的平均值及标准误（SEM）进行表征。抗性因子（RF）为适应菌株与野生型对照的EC50值之比。统计学显著性通过双侧非配对t检验进行判定。