Identification of mitochondria-related action targets of quercetin in melanoma B16 cells

Quercetin can effectively inhibit tumor growth in various tumors. However, the exact action mechanisms of quercetin against melanoma have not been comprehensively clarified, which limits the application of quercetin. Accumulating evidence has suggested that the dysfunction of mitochondria is closely linked to carcinogenesis, a better understanding of the regulation of mitochondria-related genes will shed light on providing new therapies for melanoma. In this study, we performed RNA-seq from melanoma B16 cells treated with quercetin versus controls and screened for differentially expressed genes (DEGs).

槲皮素(Quercetin)可有效抑制多种肿瘤的生长。然而，槲皮素抗黑色素瘤的确切作用机制尚未得到全面阐明，这限制了其应用。越来越多的证据表明，线粒体功能异常与肿瘤发生密切相关，深入解析线粒体相关基因的调控机制，将为黑色素瘤的治疗提供新的思路。本研究对经槲皮素处理的黑色素瘤B16细胞与对照组细胞进行了RNA测序(RNA-seq)，并筛选出差异表达基因(Differentially Expressed Genes, DEGs)。