Cyclocarya paliurus leaves alleviate obesity via regulating gut microbiota

High-sucrose diet are popular in daily life, but harmful to our health. How the high-sucrose diet influences the intestinal metabolism is still unclear. Cyclocarya paliurus leaves (CPL), as a kind of tea to alleviate metabolic diseases, is widely used by Chinese. However, the effects of CPL on high-sucrose induced obesity is unknown, and mechanisms of CPL to regulate intestinal metabolism might exist.This study aimed to describe the changes of gut microbiota and gut metabolites by high-sucrose diet, and to reveal the potential mechanisms of CPL to alleviate the high-sucrose diet induced obesity.

高蔗糖膳食在日常生活中颇为常见，却会对人体健康造成损害。目前，高蔗糖膳食如何影响肠道代谢的机制仍未明确。青钱柳叶（Cyclocarya paliurus leaves, CPL）作为一类可缓解代谢疾病的茶饮，在我国民众中应用广泛。然而，青钱柳叶对高蔗糖诱导肥胖的干预效果尚不明确，其调控肠道代谢的潜在作用机制亦有待阐明。本研究旨在阐明高蔗糖膳食对肠道菌群与肠道代谢物的影响变化，并揭示青钱柳叶缓解高蔗糖膳食诱导肥胖的潜在作用机制。