Pediatric Logistic Organ Dysfunction - 2 in Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumonia

This file contains outcome measures related to the pediatric logistic organ dysfunction.
Study Description
Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumonia (VAP) was a prospective longitudinal observational study of high risk mechanically ventilated children with systematic bacterial and viral analyses of the respiratory tract along with proteomic evaluation of the host response to determine whether specific taxa and patterns of bacterial microbiota contribute to ventilator-associated pneumonia (VAP) risk and whether bacterial communities are modulated by viral infection and host immune responses to increase risk of VAP. Analysis found that in mechanically ventilated children, microbial factors were subtly different at intubation between those who did and did not develop VAP, and changes over time were marginally associated with VAP risk, suggesting other factors may contribute to VAP. Children aged 31 days to 18 years requiring mechanical ventilation support for greater than 72 hours

本文件包含与小儿Logistic器官功能障碍（pediatric logistic organ dysfunction）相关的结局指标。

研究描述
本研究主题为呼吸机相关性肺炎（Ventilator-Associated Pneumonia, VAP）发生前的微生物组、病毒组与宿主应答，是一项针对高风险机械通气儿童的前瞻性纵向观察研究。研究对受试者呼吸道开展系统性细菌与病毒分析，并对宿主应答实施蛋白质组学评估，旨在明确两大科学问题：其一，特定细菌类群与菌群模式是否会提升呼吸机相关性肺炎（VAP）的发病风险；其二，病毒感染与宿主免疫应答是否会调控细菌群落结构，进而升高VAP发病风险。

研究分析结果显示，在机械通气儿童群体中，气管插管时发生VAP与未发生VAP的患儿，其微生物特征仅存在细微差异；随时间推移的菌群变化与VAP风险仅存在弱相关性，提示可能存在其他因素参与VAP的发生发展。

本研究纳入年龄介于31天至18岁、需接受机械通气支持且时长超过72小时的儿童。