Table_1_Migraine in the Young Brain: Adolescents vs. Young Adults.docx

Migraine is a disease that peaks in late adolescence and early adulthood. The aim of this study was to evaluate age-related brain changes in resting state functional connectivity (rs-FC) in migraineurs vs. age-sex matched healthy controls at two developmental stages: adolescence vs. young adulthood. The effect of the disease was assessed within each developmental group and age- and sex-matched healthy controls and between developmental groups (migraine-related age effects). Globally the within group comparisons indicated more widespread abnormal rs-FC in the adolescents than in the young adults and more abnormal rs-FC associated with sensory networks in the young adults. Direct comparison of the two groups showed a number of significant changes: (1) more connectivity changes in the default mode network in the adolescents than in the young adults; (2) stronger rs-FC in the cerebellum network in the adolescents in comparison to young adults; and (3) stronger rs-FC in the executive and sensorimotor network in the young adults. The duration and frequency of the disease were differently associated with baseline intrinsic connectivity in the two groups. fMRI resting state networks demonstrate significant changes in brain function at critical time point of brain development and that potentially different treatment responsivity for the disease may result.

偏头痛是一种高发于青春晚期与成年早期的疾病。本研究旨在针对两个发育阶段——青春期与成年早期，对比偏头痛患者与年龄-性别匹配的健康对照者，分析其静息态功能连接（resting state functional connectivity, rs-FC）中与年龄相关的脑变化。本研究分别在各发育组内（偏头痛患者与匹配健康对照间）以及不同发育组之间（即偏头痛相关年龄效应）评估了该病对脑连接的影响。整体而言，组内对比结果显示，青春期偏头痛患者的异常静息态功能连接范围较成年早期患者更广，而成年早期患者的异常连接更多与感觉网络相关。两组直接对比则发现多项显著差异：(1) 青春期患者的默认模式网络（default mode network, DMN）连接变化较成年早期患者更为显著；(2) 青春期患者的小脑网络静息态功能连接强度高于成年早期患者；(3) 成年早期患者的执行网络与感觉运动网络的静息态功能连接强度更高。该病的病程时长与发作频率，在两组中与基线固有连接的关联模式存在差异。功能磁共振成像（functional Magnetic Resonance Imaging, fMRI）静息态网络分析结果显示，在脑发育的关键时期，脑功能存在显著变化，这或提示该病可能存在不同的治疗反应性。