IL-22 deficiency had minimal effect on gene expression in the mouse during H. pylori infection.

At 1 months post infection, no significant difference in expression of Defb3 (p = 0.524), Lcn2 (p = 0.31), S100a8 (p = 0.944), S100a9 (p = 0.31), Cxcl1 (p = 0.413), Cxcl2 (p = 0.944) and Cxcl5 (p = 0.532) as measured between H. pylori–infected WT and infected IL-22-/- mice gastric tissue. Relative units are calculated as described in the methods, relative to GAPDH and calibrated to uninfected WT mice. Statistical analysis was performed using Mann-Whitney U (Error bars represent ± SEM).

感染后1个月时，在幽门螺杆菌（H. pylori）感染的野生型（WT）小鼠与IL-22基因缺失（IL-22-/-）小鼠的胃组织中，Defb3、Lcn2、S100a8、S100a9、Cxcl1、Cxcl2及Cxcl5的表达水平均无显著差异，各指标对应的p值分别为0.524、0.31、0.944、0.31、0.413、0.944及0.532。相对表达量按方法部分所述流程计算，以GAPDH作为内参基因，并以未感染的野生型小鼠作为校准基准。统计分析采用曼-惠特尼U检验，误差棒表示±标准误（SEM）。