Supplemental Figure S1: Contour-enhanced funnel plots

Supplemental Figure S1. Contour-enhanced funnel plots created for A) colostral IgG concentration in heat-treated versus raw colostrum, B) viscosity of colostrum in heat-treated versus raw colostrum and C) serum IgG concentration in calves fed heat-treated colostrum versus calves fed raw colostrum for all studies included in each meta-analysis. The symmetrical distribution of trials included in the meta-analysis (grey dots) around the mean difference suggests no publication bias. When asymmetry was identified the trials perceived as missing (hollow dots) were filled by trim-and-fill. When studies that appear to be missing were in low statistical significance areas, asymmetry was likely due to publication bias (Palmer et al., 2008).

补充图S1. 为A) 热处理与未处理初乳中的初乳IgG浓度，B) 热处理与未处理初乳的粘度，以及C) 喂养热处理初乳与未处理初乳的小牛血清IgG浓度绘制了轮廓增强的漏斗图，这些漏斗图涵盖了每个荟萃分析中包含的所有研究。荟萃分析中包含的试验（灰色点）围绕平均差异的对称分布表明不存在发表偏倚。当识别出不对称性时，被视为缺失的试验（空心点）将通过裁剪和填充得到补充。当看似缺失的研究处于低统计显著性区域时，不对称性很可能是由于发表偏倚所致（Palmer等人，2008年）。