Cicatricial Alopecia pathogenesis: Uniqueness or similarities between lymphocytic subtypes Lichen planopilaris (LPP) and Central centrifugal cicatricial alopecia (CCCA). Homo sapiens

Microarray analyses of LPP and CCCA was undertaken to decipher differential pathophysiological pathways leading to disease initiation and progression Overall design: Scarring alopecia consists of a collection of disorders characterized by destruction of hair follicles, replacement with fibrous scar tissue, and irreversible hair loss. Alopecia affects men and women worldwide and can be a significant source of psychological stress and depression for affected individuals. The purpose of this study was to explore Gene expression profiles in scalp tissue samples from normal control subjects (n=1(comprising 10 pooled samples)) and in matched samples obtained from affected (n=3) and unaffected (n=3) areas of the scalp in patients with Central centrifugal cicatricial alopecia (CCCA) as well with matched samples obtained from affected (n=7) and unaffected (n=7) areas of the scalp in patients with Lichen planopilaris (LPP) .

本研究通过微阵列分析（microarray analyses）解析毛发扁平苔藓（Lichen planopilaris, LPP）与中央离心性瘢痕性脱发（Central centrifugal cicatricial alopecia, CCCA）的差异病理生理通路，以阐明疾病发生与进展的分子机制。整体实验设计：瘢痕性脱发是一类以毛囊破坏、纤维瘢痕组织替代及永久性脱发为特征的疾病群。脱发在全球范围内均可累及男女患者，常给患者带来严重的心理压力与抑郁情绪。本研究旨在分析头皮组织样本的基因表达谱，样本来源包括：正常对照受试者（n=1，包含10个混合样本）；中央离心性瘢痕性脱发（CCCA）患者的病变头皮区域样本（n=3）及配对的非病变头皮区域样本（n=3）；毛发扁平苔藓（LPP）患者的病变头皮区域样本（n=7）及配对的非病变头皮区域样本（n=7）。