Table_1_Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences.docx

BackgroundLipid metabolism is associated with glucose metabolism, but whether there are variations between sexes in risk factors and prevalence of abnormal lipid metabolism in major depressive disorder (MDD) patients with glucose metabolism abnormalities remains ambiguous. In the present study, the frequency and risk factors of dyslipidemia in first-episode and drug-naïve (FEDN) MDD patients with dysglycemia were examined according to sex.
MethodsOne thousand seven hundred and eighteen FEDN MDD patients were recruited and their demographic data, clinical data, various biochemical indicators and scale assessment scores including 17-item Hamilton Rating Scale for Depression (HAMD-17), 14-item Hamilton Anxiety Rating Scale (HAMA-14), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were collected.
ResultsThe prevalence of abnormal lipid metabolism in both male and female MDD patients with abnormal glucose metabolism was higher than that in patients without abnormal glucose metabolism. Among male MDD patients with abnormal glucose metabolism, TC was positively correlated with HAMD score, TSH and TgAb levels, but negatively correlated with PANSS positive subscale scores. LDL-C was positively correlated with TSH and BMI, but negatively correlated with PANSS positive subscale scores. HDL-C was negatively correlated with TSH levels. Among females, TC was positively correlated with HAMD score, TSH, and BMI, but negatively correlated with PANSS positive subscale score. LDL-C was positively correlated with HADM score and negatively correlated with FT3 level. HDL-C was negatively correlated with TSH and BMI levels.
ConclusionThere are sex differences in the correlated factors of lipid markers in MDD patients with impaired glucose.

【背景】脂质代谢与糖代谢存在密切关联，但伴糖代谢异常的重度抑郁症（major depressive disorder, MDD）患者中，血脂异常的危险因素及患病率是否存在性别差异仍不明确。本研究按性别分组，探讨伴糖代谢异常的首发未用药（first-episode and drug-naïve, FEDN）MDD患者的血脂异常发生频率及其危险因素。【方法】本研究共纳入1718例FEDN MDD患者，收集其人口学资料、临床资料、各项生化指标及量表评估得分，包括17项汉密尔顿抑郁量表（17-item Hamilton Rating Scale for Depression, HAMD-17）、14项汉密尔顿焦虑量表（14-item Hamilton Anxiety Rating Scale, HAMA-14）以及阳性与阴性症状量表（Positive and Negative Syndrome Scale, PANSS）阳性分量表得分。【结果】伴糖代谢异常的男性及女性MDD患者，其血脂异常患病率均高于糖代谢正常的MDD患者。在伴糖代谢异常的男性MDD患者中，总胆固醇（total cholesterol, TC）与汉密尔顿抑郁量表得分、促甲状腺激素（thyroid-stimulating hormone, TSH）及甲状腺球蛋白抗体（thyroglobulin antibody, TgAb）水平呈正相关，与PANSS阳性分量表得分呈负相关；低密度脂蛋白胆固醇（low-density lipoprotein cholesterol, LDL-C）与TSH及体重指数（body mass index, BMI）呈正相关，与PANSS阳性分量表得分呈负相关；高密度脂蛋白胆固醇（high-density lipoprotein cholesterol, HDL-C）与TSH水平呈负相关。在女性患者中，TC与汉密尔顿抑郁量表得分、TSH及BMI呈正相关，与PANSS阳性分量表得分呈负相关；LDL-C与汉密尔顿抑郁量表得分呈正相关，与游离三碘甲状腺原氨酸（free triiodothyronine, FT3）水平呈负相关；HDL-C与TSH及BMI水平呈负相关。【结论】伴糖代谢受损的MDD患者，其血脂标志物的相关影响因素存在性别差异。