Antibacterial Cu or Zn-MOFs Based on the 1,3,5-Tris-(styryl)benzene Tricarboxylate

Metal–organic frameworks (MOFs) are highly versatile materials. Here, two novel MOFs, branded as IEF-23 and IEF-24 and based on an antibacterial tricarboxylate linker and zinc or copper cations, and holding antibacterial properties, are presented. The materials were synthesized by the solvothermal route and fully characterized. The antibacterial activity of IEF-23 and IEF-24 was investigated against Staphylococcus epidermidis and Escherichia coli via the agar diffusion method.These bacteria are some of the most broadly propagated pathogens and are more prone to the development of antibacterial resistance. As such, they represent an archetype to evaluate the efficiency of novel antibacterial treatments. MOFs were active against both strains, exhibiting higher activity against Staphylococcus epidermidis. Thus, the potential of the developed MOFs as antibacterial agents was proved.金属有机框架（metal–organic frameworks, MOFs）是一类通用性极强的功能材料。本研究报道了两款新型MOFs，分别命名为IEF-23与IEF-24：二者以具备抗菌活性的三羧酸连接配体与锌、铜阳离子为构筑基元，自身亦拥有抗菌性能。该类材料通过溶剂热法合成，并经全面表征。本研究采用琼脂扩散法，探究了IEF-23与IEF-24对表皮葡萄球菌（Staphylococcus epidermidis）及大肠杆菌（Escherichia coli）的抗菌活性。这两类细菌是传播范围最广的病原菌之一，且更易产生抗菌耐药性，因此可作为评估新型抗菌疗法有效性的典型模型。实验结果显示，两款MOFs对上述两种菌株均表现出抗菌活性，且对表皮葡萄球菌的抑制效果更为显著。由此证实了所制备的MOFs作为抗菌剂的应用潜力。