studies of magnesium-induced osteogenesis

In recent years, magnesium (Mg) has been extensively studied for manufacturing biodegradable orthopedic devices. Besides other advantages, researches have shown that magnesium-based implants can stimulate osteogenesis thus accelerating orthopedic trauma recovery, but its molecular mechanism is not fully understood. Meanwhile, long non-coding RNA (lncRNA) has been found to play vital role in regulating osteogenic differentiation. This study aims to explore the role of lncRNA in magnesium induced osteogenesis.

近年来，镁（Mg）因用于制备可降解骨科植入器械而受到广泛研究。除具备其他优势外，已有研究证实，镁基植入物可刺激成骨作用，进而加速骨科创伤修复，但其相关分子机制尚未完全阐明。与此同时，长链非编码RNA（lncRNA）被发现于成骨分化的调控过程中发挥至关重要的作用。本研究旨在探究长链非编码RNA在镁诱导成骨过程中的具体作用。