Proteomics analysis of cerebrospinal fluid (CSF) from multiple sclerosis patients

Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represents an unmet need. Neural precursor cells (NPCs) transplanted in animal models of multiple sclerosis promote neuroprotection and remyelination by releasing molecules sustaining trophic support and neural plasticity. We present the results of STEMS, a single dose escalation phase I clinical trial, evaluating the feasibility, safety, and tolerability of intrathecally transplanted human fetal NPCs (hfNPCs) in 12 PMS patients.

针对进展型多发性硬化（progressive multiple sclerosis, PMS）、融合神经保护与免疫调节功能的创新促再生治疗策略，目前仍存在未被满足的临床需求。在多发性硬化动物模型中移植的神经前体细胞（neural precursor cells, NPCs）可通过释放维持神经营养支持与神经可塑性的分子，发挥神经保护与髓鞘再生的作用。本研究报告了STEMS试验的结果：这是一项单剂量递增I期临床试验，旨在评估12名PMS患者鞘内移植人胎儿神经前体细胞（human fetal NPCs, hfNPCs）的可行性、安全性与耐受性。